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阶段3间皮瘤万博专业版

Expert Fact Checked

此页面由医学评论James Stevenson, M.D.on February 6, 2019. For information on our content creation and review process read our编辑准则。如果您发现错误或对我们的内容有评论或问题,请联系我们

James Stevenson, M.D.胸部医学肿瘤学家

与间皮瘤幸存者交谈万博专业版

  • Connect with a 15-year pleural mesothelioma survivor
  • 关于治疗和生存的第一手信息
  • 努力传播有关间皮瘤的希望和灵感万博专业版
与希瑟联系

在第3阶段,间皮瘤癌症已万博专业版扩散到附近的组织,器官和/或淋巴结。结果,与较早阶段的症状相比,第三阶段症状更为突出。最常见的3期间皮瘤形式的生存率为16到26个月。万博专业版


01. Overview

什么是3期间皮瘤?万博专业版

第3期间皮瘤被认万博专业版为是该疾病的晚期阶段。在此阶段,症状可能变得突出和可识别。

第3期间皮瘤的特征万博专业版

  • Cancer转移(spreads) to tissue and organs near the cancer’s origin.
  • 癌症也可能扩散到附近的淋巴结。
  • 胸膜间皮瘤癌症可万博专业版以进一步归类为3A期或第3B期。

第3阶段和第4阶段胸膜间皮瘤之间的一个重要差异是,第4阶段表示扩散到远处的器官和组织。万博专业版

与第3阶段相比,第4阶段的腹膜间皮瘤通常涉及扩散到其他区域或较大肿瘤的存在。万博专业版

间皮瘤的分期万博专业版

Staging is an important way to determine prognosis and treatment options. Common mesothelioma staging systems examine tumor location, lymph node involvement and spreading. Mesothelioma type and cell type also help doctors understand the cancer’s progression and a patient’s life expectancy. (Read more about lymph node involvement below)

02. Stage 3 Symptoms

3期间皮瘤的症状是什么?万博专业版

By stage 3,万博专业版间皮瘤症状与癌症的早期阶段相比,更激烈,可能是严重的。

阶段3间皮瘤症状万博专业版*

  • 胸或腹痛
  • Chest tightness
  • 咳嗽
  • 呼吸困难(呼吸困难)
  • Fatigue
  • 发烧
  • 液体积聚
  • Weight loss

*List is a combination of common pleural, peritoneal, pericardial and testicular symptoms

第3阶段患者经常接受姑息治疗以缓解症状。医生可能会在治疗计划中建议姑息治疗,以减少患者的不适。

03. Stage 3 Types

阶段3间皮瘤万博专业版by Type

万博专业版间皮瘤诊断,医生将确定阶段和间皮瘤类型。万博专业版这type of mesotheliomawill impact staging protocol.

阶段3胸膜间皮瘤万博专业版

胸膜间皮瘤万博专业版is the most commonly diagnosed type of the cancer. Doctors have established three staging systems for this type:

  • 这Butchart system
  • 这Brigham staging system
  • TNM系统

TNM系统是最常用的。的系统em looks at the size and extent of mesothelioma tumors (T), lymph node involvement (N) and metastasis (M). Under the TNM system, stage 3 malignant pleural mesothelioma is classified further into stage 3A and stage 3B.

在第3A阶段,胸膜间皮瘤:万博专业版

  • 癌细胞存在于胸膜(肺部内壁)和胸部的一侧。
  • Cancer may have also spread to nearby lymph nodes, the chest wall or lining of the heart.

阶段3B胸膜间皮瘤涉及许多与3A相万博专业版同的特征。但是,3B期患者可能患有远距离淋巴结受累,癌症扩散到胸部另一侧的肺部内膜。

阶段3腹膜间皮瘤万博专业版

恶性腹膜间皮瘤万博专业版占所有诊断的15-20%。由于其稀有性,腹膜间皮瘤没有自己的分期系统。万博专业版

Instead, mesothelioma doctors may use the Peritoneal Cancer Index (PCI). The PCI grades tumors in distinct areas of the abdomen and then totals the scores. A score ranging from 21 – 30 indicates stage 3 peritoneal mesothelioma.

万博专业版在此阶段,间皮瘤肿瘤位于腹部,但可能已扩散到附近的器官和淋巴结。某些阶段3腹膜间皮瘤病例显示胸壁和整个腹腔的癌症万博专业版生长。

Stage 3 Pericardial Mesothelioma

心包间皮瘤万博专业版占诊断的1-2%。由于研究有限,医生尚未建立心包间皮瘤分期系统。万博专业版

心包间皮瘤万博专业版tumors are often aggressive and fast-growing. When these tumors are detected, the cancer has often spread:

  • 整个胸腔
  • 到附近的器官
  • 到附近的淋巴结

心包间皮瘤万博专业版may also spread to the lungs in some cases.

具有这种形式间皮瘤的患者可以在晚期或死后诊断。万博专业版

阶段3睾丸间皮瘤万博专业版

睾丸间皮瘤万博专业版没有建立的登台系统。医生使用一般分期原则来诊断疾病。第三阶段的睾丸间皮瘤诊断可能表明癌症已经在万博专业版睾丸的衬里之外扩散。与第1阶段或第2阶段相比,此阶段患者的治疗选择可能更有限。

04. Stage 3 Prognosis

阶段3间皮瘤预后万博专业版

Stage 3 mesothelioma prognosis is less favorable than earlier stages. In stage 3, the disease has become more invasive. As such, aggressive surgical treatments may no longer be an option.

除了传播的程度外,其他因素还可能影响个人的万博专业版间皮瘤预后

影响3期间皮瘤预后的因素万博专业版

  • Tumor location:这location of a tumor determines if it can be removed. If a patient’s tumor(s) can be removed, the patient may have a better prognosis.
  • 细胞类型:Patients diagnosed with上皮性间皮瘤万博专业版通常比被诊断的人更有利的期望sarcomatoid mesothelioma。Life expectancy for patients with双相间皮瘤万博专业版will depend upon the percentage of epithelioid versus sarcomatoid cells.
  • Patient age:年轻的3期间皮瘤患者的寿命通常比万博专业版现阶段诊断的老年患者更长。
  • 总体健康:患有糖尿病或慢性阻塞性肺疾病(COPD)等疾病患者的预后可能不佳。

阶段3间皮瘤预期万博专业版寿命

预后和life expectancy for stage 3 mesothelioma will vary from patient to patient. Mesothelioma life expectancy is an estimate of how long a patient will survive. Stage 3mesothelioma life expectancy根据许多因素,例如患者的健康病史,细胞类型和癌症类型而有所不同。

您可以在3阶段间皮瘤中生活多长时间?万博专业版

这median survival for stage 3 pleural mesothelioma is 16 months. Studies show stage 3 peritoneal mesothelioma patients have a median survival of 56 months.

了解淋巴结的参与和预期寿命

通过第3期间皮瘤,癌细万博专业版胞可能已扩散到附近的淋巴结。这表明该疾病的更晚期。

淋巴结和淋巴细胞是人体免疫系统的一部分。淋巴结从附近的身体组织收集废物,病毒和细菌。因此,它们是连接许多组织的高速公路。

如果癌细胞扩散到淋巴结,它们与人体其余部分的互连会导致转移。这意味着癌症可以通过淋巴管或血液扩散到多个位置。

一旦癌症扩散到淋巴结,万博专业版患者的预期寿命可能更短。淋巴结受累可能会限制治疗选择,但研究人员继续测试晚期间皮瘤的疗法。万博专业版

阶段3间皮瘤存活万博专业版率

Mesothelioma survival ratescontinue to increase as researchers and mesothelioma doctors discover new treatment techniques. Survival rates for stage 3 mesothelioma cancer are typically recorded at 2- and 5-year intervals.

阶段3胸膜间皮瘤万博专业版Survival Statistics

  • 3期胸膜间皮瘤的2年生存率为29%。万博专业版
  • 这5-year survival rate for stage 3 pleural mesothelioma is 6%.
  • 第3阶段胸膜间皮瘤的中位生存期为16个月(相比之下,第4阶段为12个月)。万博专业版

阶段3腹膜间皮瘤生存统计万博专业版

  • 这2-year survival rate for stage 3 peritoneal mesothelioma is 71%.
  • 第3期腹膜间皮瘤的5年生存率为48%。万博专业版
  • 这median survival for stage 3 peritoneal mesothelioma is 56 months (compared to 26 months for stage 4).

Stage 3 Testicular and Pericardial Mesothelioma Survival

Given the rarity of testicular and pericardial mesothelioma, data on the associated stage 3 survival rates is unavailable. A mesothelioma specialist can advise pericardial and testicular mesothelioma patients on their individual prognosis.

05. Can It Be Cured?

可以治愈3期间皮瘤吗?万博专业版

目前有狗万1.0 。Mesothelioma patients diagnosed at stage 3 typically have a less favorable prognosis than those diagnosed at earlier stages. However, doctors are evaluating new and existing treatments to extend patient life expectancy.

阶段3间皮瘤万博专业版幸存者

Thanks to ongoing advancements in treatment, some stage 3 mesothelioma patients outlive their initial prognosis. Although stage 3 is considered a late stage of mesothelioma, some patients are still able to undergo aggressive treatment.

最近检查的一项研究双向化疗的潜力用于晚期腹膜间皮瘤。万博专业版在接受双向化疗后,一半的参与者能够接受更具侵略性的治疗,包括手术。这组患者的总生存率约为83%。

06. Stage 3 Treatment

阶段3间皮瘤万博专业版治疗

分期是确定患者的重要因素mesothelioma treatment plan。Accurate staging gives physicians insight into the most appropriate treatment options for their patients.

在第3阶段,患者可能有资格接受治疗疗法,例如手术,化学疗法和放射线。万博专业版间皮瘤医生可能会建议一种多模式方法,其中涉及两种或多种治疗类型的组合。这些治疗可能会提高预期寿命。

这些标准治疗方法也可以疼痛地应用于缓解症状。姑息治疗is often a large component of stage 3 treatment to provide the patient with the highest quality of life possible.

阶段3间皮瘤万博专业版治疗Options

  • Surgery
  • Chemotherapy
  • Radiation therapy
  • 多模式疗法
  • 临床试验
  • 免疫疗法
  • 姑息治疗
  • 替代疗法

Surgery

Some patients with stage 3 mesothelioma may still be eligible for invasive surgery to remove tumors. In rare cases, pleural mesothelioma patients in stage 3 may qualify for an胸膜外肺切除术。该过程清除了整个受影响的肺及其内膜(胸膜),围绕心脏和隔膜衬里。

对于第3阶段患者,不符合侵略性手术的资格,可以选择姑息治疗手术。在第3阶段患者中,可以减轻症状和改善生活质量的手术更为普遍。姑息手术包括:

  • Pleurodesis:对肺部间皮瘤患者进行的一项手术,肺部周围有液体积聚。万博专业版手术关闭胸腔腔内的空间,并排除多余的液体。
  • 胸膜穿刺术(胸腔话语):消除胸腔液积聚的程序。排出的液体可以缓解呼吸急促等症状。
  • 子宫政植:对腹膜间皮瘤患者进行的手术。万博专业版手术会从腹部区域排出多余的液体。

Chemotherapy

For stage 3 patients with advanced spreading, chemotherapy may be the primary treatment option. Patients who are able to undergo surgery may also receive chemotherapy to kill remaining cancer cells.

许多间皮瘤万博专业版患者通过IV接受化学疗法。静脉化疗药物用于延长预期寿命并改善生活质量。医生可能会建议使用Pemetrexed,Cisplatin和/或贝伐单抗用于间皮瘤。万博专业版

放射治疗

Radiation therapy may be used palliatively. It can be used to shrink tumors and reduce symptoms, such as chest pain and difficulty breathing. In some cases, radiation may be administered after surgery to prevent localized tumors from growing.

多模式疗法

Studies have shown the use of two or more mesothelioma treatments may extend patient life expectancy. A multimodal treatment plan can be aggressive and may not be suitable for every patient. A mesothelioma doctor can determine whether a stage 3 patient is eligible.

Clinical Trials

研究人员和医生一直在治疗恶性间皮瘤。万博专业版临床试验允许医生对间皮瘤患者进行新兴治疗。万博专业版如果后期癌症患者对标准治疗方案没有反应,则可能有资格进行临床试验。

免疫疗法

免疫疗法是晚期间皮瘤患者的可行,新兴的选择。万博专业版临床试验正在测试3阶段患者的免疫疗法药物。

In aclinical trial at the Baylor College of Medicine Lung Institute,研究人员正在测试与新药物MTG201结合使用免疫疗法药物Nivolumab的有效性。该试验的第2阶段将向先前接受化疗并且仍然看到疾病进展的患者开放。

这trial is moving into phase 2 after researchers obtained positive results in the phase 1 trial. The next phase of the study will include patients at all stages of the mesothelioma, including stage 3.

姑息治疗

治疗options for advanced-stage mesothelioma can be limited. As a result, palliative care is common among stage 3 and 4 patients. Palliative treatments can lessen symptoms and make patients more comfortable.

患有3期间皮瘤的患者具有更明显的症状,可以从万博专业版姑息治疗中受益。

In some cases, advanced stage patients may receive standard forms of treatment and palliative therapies. Studies have shown patients who receive standard and palliative care may have better quality of life and survival rates versus those receiving palliative care alone.

替代疗法

In addition to standard treatment options, patients may consider alternative therapies. These complementary therapies can help reduce symptoms and treatment side effects. Alternative therapies may be used at any time during a patient’s treatment journey.

互补的替代治疗包括:

  • Herbal and nutritional supplements
  • Hypnotherapy
  • 癌症的光治疗
  • 冥想
  • 癌症的反射学
  • 瑜伽和个人健身

尽管第3期间皮瘤表示癌症已经晚期癌万博专业版症,但患者可以寻求改善预后的治疗方法。最近的研究发现,接受标准或新疗法的3阶段患者的生存率提高了。患者应与间皮瘤医生讨论他们的选择。万博专业版

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