Navelbine® (Vinorelbine) for Mesothelioma

02. Vinorelbine and Mesothelioma

How Does Navelbine (Vinorelbine) Treat Mesothelioma?

Vinorelbine is a chemotherapy drug that interferes with cell growth. Mesothelioma patients may receive it as part of their treatment plan. Vinorelbine is not a common chemotherapy drug for万博专业版。However, certain patients may benefit from it. For example, vinorelbine may be an option for patients who did not respond well to other first-line treatment options.Mesothelioma doctorscan determine if vinorelbine treatment might be appropriate.

Vinorelbine通过靶向具有细胞分裂的特定蛋白质来起作用。它也可能通过干扰DNA和RNA合成而导致癌细胞死亡。这可能会阻碍癌细胞的生长。

Combining vinorelbine with other chemotherapy drugs may result in more effective treatment. For example, it is sometimes used withcisplatin。Vinorelbine和Cisplatin使用不同的机制杀死快速分散的癌细胞。以这种方式组合药物机制会增加消除所有癌细胞的机会。

用于胸膜间皮瘤的Navelbine（Vinorelbine）万博专业版

There is currently no standard treatment for mesothelioma using vinorelbine. Research has examined ways it may offer benefits for treating malignant pleural mesothelioma. Researchers have investigated vinorelbine in the following instances:

• First-line treatment:Vinorelbine已被用作一线治疗。医生可以将其用作单一药物或与另一种化学疗法药物结合使用。
• Second-line treatment:Vinorelbine has been used as a second-line treatment. It may be offered as a single agent in this context. It may also be an option for patients who are not eligible for clinical trials.

Studies of vinorelbine for pleural mesothelioma have shown a median survival from about 6 to 17 months. This range includes patients treated with vinorelbine alone and in combination with other drugs. Several studies have combined vinorelbine with more standard forms of mesothelioma chemotherapy treatment.

• One study used vinorelbine after a regimen of platinum chemotherapy pluspemetrexed。Median overall survival was about 6 months.
• Another study used vinorelbine as a single agent in first-line treatment. Results showed pleural mesothelioma patients had a median overall survival of almost 14 months.
• 另一项研究使用乙烯甲胺作为胸膜间皮瘤患者没有资格万博专业版surgery。In the study, researchers combined vinorelbine and cisplatin as a first line of treatment. Median overall survival was almost 17 months.

研究人员继续研究Vinorelbine作为间皮瘤治疗的使用。万博专业版它已获得美国食品药品监督管理局（FDA）的批准non-small cell lung cancer(NSCLC)。目前还没有批准治疗另外一些er diseases, such as mesothelioma. However, vinorelbine has been studied as a treatment option for:

• 乳腺癌
• Cervical cancer
• 霍奇金淋巴瘤
• 万博专业版
• Multiple myeloma

目前,vinorelbine不是常见的mesothelioma treatment. But it may be useful in certain situations. Mesothelioma doctors can decide if vinorelbine is an appropriate treatment.

03. What to Expect

What to Expect During Treatment

Vinorelbine是间皮瘤化学疗法治疗的几种不同选择之一。万博专业版它是静脉内给药的。患者可以期望在医疗保健专业人员的监督下接受治疗。

Vinorelbine may be administered alone or in combination with other chemotherapy drugs. A specialist can determine which combination is most appropriate for a patient. Infusions generally occur over the course of six to ten minutes. They are administered in specific dosages and on a fixed schedule. Dosages may vary based on the type of cancer. Some FDA-approved dosages for NSCLC are as follows:

Healthcare providers attend to patients during infusions. They track vitals to help address problems if they occur. Patients can also alert providers to any discomfort they may feel during their infusion.

Patients may undergo several cycles of treatment. A doctor will determine how many cycles are appropriate. The number of cycles can depend on how well a patient responds to vinorelbine. A doctor may decide whether to stop treatment if risky side effects occur.

准备约会

There are several ways mesothelioma patients can prepare for their vinorelbine chemotherapy appointment. Preparation may help reduce stress and discomfort and help avoid any unnecessary complications. In the lead up to their appointment, patients can ask their doctor questions about treatment.

To prepare for their chemotherapy appointment, mesothelioma patients may also want to:

• Arrange transportation:Patients may feel low-energy or drowsy after their infusion. They may want to arrange a safe ride from the hospital.Transportation servicesmay be available if a friend or family member cannot provide a ride.
• 安排带一个同伴：设施通常允许患者带朋友或家人任命。同伴可以保留患者公司，帮助提出问题并记笔记。
• Dress comfortably:Patients can limit discomfort during infusions by dressing in layers and non-constrictive clothing.
• Pack a bag:Patients may get hungry, thirsty or bored during infusions. Packing a bag with certain items may make treatment less uncomfortable. Patients may want to pack snacks, a small meal or a beverage. Crafts and reading materials may also help with boredom.
• 准备轻松的输入后时间表：Patients may want to spend time resting and recovering after their appointment. A friend or family member may be able to help with chores, errands and meal preparation. Patients may also want to notify their employer that they may need time off.

Healthcare providers may also ask patients about their cancer journey during their appointment. This can help them provide better care. Patients may want to organize their medical documents in one place. This can help avoid stress and create a smoother appointment experience.

Managing Treatment and Follow-Up Care

Patients may go through multiple treatment cycles with vinorelbine. Doctors have several ways to manage complications.

Mesothelioma doctors may give patients treatment-management instructions. Patients should make sure to follow any instructions. To take care of themselves during treatment, patients may also want to:

• 避免大量的人群或病人以防止感染
• 喝大量液体以避免脱水
• Use caution when doing tasks that need mental alertness until the side effects of vinorelbine are known
• Wash hands to reduce the risk of infection

对于患者来说，与医生一起参加后续约会也很重要。这些任命是讨论和解决任何的机会治疗副作用。Doctors will be able track mesothelioma patients’ progress. They may draw blood to check blood cell levels and organ functions. Doctors can also help manage side effects and determine if it is safe to continue treatment.

04. Benefits of Vinorelbine

Navelbine (Vinorelbine) Benefits

Vinorelbine may benefit mesothelioma patients in certain situations. This chemotherapy is generally well-tolerated. This means it has a relatively low incidence of side effects compared to other chemotherapy drugs. As a result, it may be an option for patients who are unable to handle negative side effects associated with other treatments. It may also be useful as a second-line therapy for patients ineligible for clinical trials.

Vinorelbine is not a common mesothelioma treatment. Its benefits for mesothelioma have not been fully explored. At least one study found promising survival results for patients with pleural mesothelioma. Patients who received a first-line treatment of cisplatin and vinorelbine had a median survival of 16.8 months. It is possible that future studies will reveal further benefits.Mesothelioma researchersare always looking for more effective treatments for this rare disease.

05. Side Effects of Vinorelbine

纳维尔金（Vinorelbine）副作用

Mesothelioma patients who receive vinorelbine treatment may experience side effects. Common side effects include anemia, nausea, vomiting and weakness. Different factors may result in a variety of side effects. For example, drug and therapy combinations may cause different side effects than treatment with vinorelbine alone.

Neutropenia is a potential side effect of vinorelbine. It is an abnormally low count of white blood cells called neutrophils. If this side effect occurs, doctors may reduce dosage or pause treatment altogether. This condition can make people more susceptible to infection. Discontinuing vinorelbine usually has a positive effect on white blood cell count. Doctors generally check patients for neutropenia before each dose of vinorelbine.

患者可以在治疗前向间皮瘤医生询问副万博专业版作用。医生可以在发生时帮助管理副作用和不良事件。

Managing Side Effects

间皮万博专业版瘤患者的医疗团队可以帮助管理Vinorelbine治疗副作用。如果患者遇到任何不良反应，应与他们的医生交谈。医生可以评估情况并提供建议以改善患者的生活质量。

Nausea and vomiting are common vinorelbine treatment side effects. Adjustingnutrition during and after chemotherapycan help manage nausea. A doctor may also prescribe anti-nausea medication. Patients should make sure they take any medication as prescribed.

Another common vinorelbine side effect is constipation. Patients are advised to follow a diet rich in fiber and stay hydrated. They may also use stool softeners. A营养师也许能够推荐饮食计划，以帮助症状并在治疗过程中维持营养。

Certain drugs andsupplementsmay claim to help with treatment side effects. These include:

• Herbs
• Minerals
• 非处方药物
• Vitamins

患者应在服用任何一项之前咨询医生。他们可能会干扰治疗。医生可以确定药物或补充剂是否可以安全服用Vinorelbine。

06. Vinorelbine资格

谁有资格获得Navelbine（Vinorelbine）？

Specialists can determine vinorelbine chemotherapy eligibility based on several factors. There is currently no standard mesothelioma treatment with vinorelbine. Patients should talk with their doctors to determine if they may be eligible for vinorelbine treatment. Doctors will know the potential benefits and risks for individual patients.

Vinorelbine可以用作胸膜间皮瘤治疗计划的一部分。万博专业版患者可能没有资格获得Vinorelbine，原因有几个，包括：

• 患者的性能状况较差。
• The patient is pregnant.
• The patient lacks the BRCA1 gene.

Performance status is a measure of a person’s ability to engage in daily activities, rated on a scale from zero to five. Pleural mesothelioma patients with a performance status of zero to two may be eligible to receive vinorelbine. A performance status of zero indicates no impairment. Performance status of two indicates the patient is capable of self-care but unable to engage in work activities. Patients rated higher than two may be ineligible for vinorelbine.

Doctors can help patients explore other treatment options if they are ineligible for vinorelbine.

07. Vinorelbine Studies

针对胸膜间皮瘤的Navelbine（Vinorelbine）的临床试验和研究万博专业版

Vinorelbine间万博专业版皮瘤治疗是正在进行的研究和clinical trials。Currently, vinorelbine is not a common part of a mesothelioma treatment plan. But researchers continue to look for new ways to treat this rare disease.

目前还没有标准的二线mesothelioma treatment after chemotherapy. Researchers in one clinical trial looked at the potential use of vinorelbine for this purpose. The trial enrolled 154 pleural mesothelioma patients. It indicated improved progression-free survival for patients treated with vinorelbine. Median progression-free survival was:

• 用乙烯宾治疗的患者：4.2 months
• Patients not treated with vinorelbine:2.8 months

These results suggest vinorelbine may be a useful second-line treatment for pleural mesothelioma.

Researchers continue to study new ways to use this chemotherapy drug to deliver more effective treatment. Mesothelioma doctors can determine if vinorelbine is appropriate for a patient.