01. Overview
Pemetrexed（Alimta®）如何用于治疗间皮瘤万博专业版
根据国家综合癌症网络（NCCN）的数据，Pemetrexed可以作为单一药物治疗或与其他化学药物结合作为所有类型的间皮瘤的一线治疗。万博专业版对于非候选手术的患者，彭茶疗法通常是建议的一线治疗。作为一个的一部分multimodal treatment plan, the American Society of Clinical Oncology (ASCO) notes that pemetrexed can be given either before or after surgery, typically ranging between 4 – 6 treatment cycles. If patients respond favorably to the treatment, they may be allowed to take a break from continued化学疗法。
通过静脉注射给患者垂体，大约需要10分钟才能完成。该过程每三周进行几个周期，具体取决于患者的个体情况。万博专业版如果癌症保持稳定或减少，则间皮瘤患者可能能够保留该药物作为维护治疗计划的一部分。
Depending on how the body responds to the treatments, a patient’s healthcare team can perform blood tests to determine whether or not the dosage needs to change or if treatment needs to be slowed or stopped altogether. Factors that could alter the treatment schedule include a patient’s overall health, cancer progression, cell type and other prior or future treatments.
Pemetrexed is also supplemented with folic acid, taken orally, and Vitamin B12 injections. This is meant to reduce the risk of a patient developing side effects associated with their chemotherapy regimen.
02.副作用
Possible Side Effects of Pemetrexed (Alimta®)
对于诊断患有恶性间皮瘤的患者，涉及使用Alimta®的治疗已被证明有效地杀死万博专业版了癌细胞。但是，患者可能会面临许多副作用，这些副作用可能会根据患者对治疗的反应以及是否单独给出或与其他疗法结合使用而有所不同。就其本身而言，Alimta®通常具有良好的耐受性，但可能会导致副作用，例如疲劳，食欲不振和恶心。像许多其他化学疗法药物一样，尽管患者对服用alimta®的患者却很低，但患者也有患者脱发或稀疏的风险。
Alimta® has also been less commonly associated with more serious side effects, ranging from painful skin reactions to kidney damage, lung issues and radiation recall. Radiation recall occurs when the body has been treated with radiation prior to receiving Alimta® and generally results in swelling or blistering where the radiation was given.
患者还应确保讨论其他medications and supplements they are taking with their doctors, as it could cause adverse reactions with pemetrexed. According to a 2017 study, researchers noticed that blood problems could develop in patients taking both nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and pemetrexed with carboplatin, especially for those with renal insufficiencies.
的制造商爱宁达®已经说了-the-counter medications like aspirin or ibuprofen may be given in low doses. Higher doses of these common medications are not recommended because there isn’t enough information about their interactions with pemetrexed.
03. Studies
Studies Associated With Pemetrexed (Alimta®)
2003年，在获得FDA批准之前，一项3阶段临床研究表明，接受Pemetrex和顺铂的患者比单独接受顺铂的患者长约三个月（12.1个月，而对照组为9.3个月）。接受联合疗法的组的患者反应率也更高，而不是顺铂的单一药物治疗。
在最近的研究中，研究人员指出peritoneal mesotheliomaalso responded to treatments using pemetrexed as either a single agent or combined with a platinum-based drug like cisplatin. According to one study, patients who received pemetrexed alone had a 1-year survival rate of about 42%, while more than 57% of those who received the drug combined with cisplatin survived for one year. On average, peritoneal mesothelioma patients survive six months to one year.
在2017年，另一项研究对24例恶性腹膜间皮瘤患者接受了刺皮和顺铂治疗，并产生了两种完整的反应和9个万博专业版部分反应，总计为45.8％的缓解率。使用药物组合，患者还看到中位总生存期为15.8个月。
