Scientists and doctors use mesothelioma research studies to improve diagnosis and treatment of this asbestos-related cancer. Some researchers investigate basic mesothelioma science, such as how the cancer grows and spreads. Research and clinical trials can help doctors discover new treatments and improve prognosis for their patients.
01.研究重要性
间皮瘤研究的重要性万博专业版
万博专业版是一个罕见的癌症，每年在美国有大约3,000例新诊断的病例。由于其稀有性，间皮瘤周围的数据不如其他更常见的癌症，例如肺癌。万博专业版由于各种原因，恶性间万博专业版皮瘤研究对患者起着至关重要的作用。
改进的诊断工具
Early detection can influence间皮瘤患者的预后万博专业版。如果该疾病在早期被捕，则可以提供更多治疗选择。治疗也可能更具侵略性，患者通常会更好mesothelioma survival ratesthan those diagnosed at stage 3 or stage 4.
Blood Tests and Biomarkers
最近改进的领域万博专业版间皮瘤诊断工具是blood tests and biomarkers。研究人员继续发现可以表明间皮瘤诊断的血液中的生物标志物或血液中的物质显示出间皮瘤的症状或证明了石棉暴露的史，这是该疾病唯一已知的原因。万博专业版
One of the newest biomarkers is HMGB1. A recent study used HMGB1 to evaluate study participants’ past asbestos exposure. Researchers successfully used HMGB1 to:
- Distinguish asbestos-exposed individuals from those without exposure
- 区分间皮瘤患者与没有石棉万博专业版暴露的个体
- Distinguish mesothelioma patients from healthy individuals with a history of asbestos exposure
Blood tests cannot diagnose mesothelioma on their own. However, they can prompt physicians to conductimaging scansand活检。
万博专业版间皮瘤呼吸测试
One promising new diagnostic tool is a万博专业版间皮瘤呼吸测试。在此测试中，一个人会呼吸到设备或容器中。然后，机器或工具将分析他们的呼吸。通过分析，医生可能能够诊断间皮瘤。万博专业版
Gas-chromatography-mass spectrometry (GC-MS) is a type of breath analysis tool. GC-MS has been 97% accurate in distinguishing mesothelioma patients from healthy asbestos-exposed individuals.
More research is required to validate this technology. At least one mesothelioma breath test clinical trial is currently working on that validation.
新兴治疗和临床试验
恶性间皮瘤患者通常面万博专业版临从1到5。5年以上的生存率。但是，进步mesothelioma treatment提供希望改善预后的希望。
Before becoming a treatment option, newer treatments are tested inclinical trials。Patients must meet certain criteria to participate, but clinical trials are often an option for those not responding to the standard of care. If successful, clinical trials have the potential to gain FDA approval and status as a first- or second-line treatment option.
表现出一些成功的新疗法包括基因治疗,免疫疗法and光动力疗法。尤其是光动力疗法是最近一些研究的重点。胸皮间皮瘤患者在万博专业版光动力疗法后长达7.3年与手术和化疗相结合。
Improved Standard Treatments
也已经对现有的护理标准进行了进步，包括手术，化学疗法和放射线。其中一些进步改善了这些疗法的结合方式。万博专业版间皮瘤专家继续测试和改善这些治疗方法。
Chemotherapy and Immunotherapy
The National Comprehensive Cancer Network (NCCN) recently updated their guidelines to include a combination of Alimta®, cisplatin and bevacizumab as a first-line treatment, combining chemotherapy drugs with a drug that targets tumor blood vessels. The NCCN recognizes that this is only an option for patients not eligible for surgery. In a recent study of 448 patients, half treated with all three drugs and half treated without bevacizumab, overall survival improved for those treated with the full combination.
这三种药物的结合将生存期延长至18.8个月。但是，仅Alimta®和顺铂的组合中位生存期为16.1个月。
免疫疗法药物，例如pembrolizumab和nivolumab/ipilimumab，也显示出有效性作为二线选择的有效性，对于皮皮瘤在一线治疗后已进展的患者。万博专业版现在，这些药物作为当前NCCN指南中推荐的疗法包括在内。
创新的辐射疗法
研究ers have studied how combined radiotherapy and surgery can be more effective in treating mesothelioma. One radiation therapy advancement is the SMART method. SMART stands for Surgery for Mesothelioma After Radiation Therapy.
This treatment plan begins with radiation therapy and is followed by a surgery calledextrapleural pneumonectomy。在一项研究中，智能方法将上皮间皮瘤患者的中位生存期扩大到42.8个月。万博专业版
SMART的研究人员和拥护者继续尝试提高此选项的疗效，还可以在放射治疗和手术前的免疫疗法的结合中取得成功。还研究了肺炎胸膜切除术后的辐射疗法，称为IMRT，应用于胸膜表面，并发现具有有希望的有效性是安全的。
Resources for Mesothelioma Patients
Improved Palliative Care
Palliative careplays an important role in mesothelioma treatment, helping reduce symptoms for patients. As cancer cells spread throughout the body, patients may experience more symptoms, as well as side effects from treatments. Palliative care can offer symptomatic relief and a higher quality of life.
万博专业版间皮瘤案例研究继续分析间皮瘤患者和间皮瘤幸存者的特定姑息治疗的有效性。例如，最近的研究研究了放射治疗对胸皮间皮瘤患者的姑息性作用。万博专业版
In one study, palliative radiotherapy was reported to improve symptoms in more than 50% of mesothelioma patients. Researchers continue to look into how radiation therapy can be used palliatively on its own and in combination with other treatment techniques.
了解间皮瘤万博专业版
胸膜间皮瘤万博专业版是最常见的类型，占所有病例的80-90％，其次是腹膜，为15-20％。心包和睾丸间皮瘤每个占所有间皮瘤病例的1％或更少。万博专业版也有罕见的细胞类型会影响更少的个体。案例研究最常见的是恶性胸膜间皮瘤，但研究仍然有限。万博专业版
As more cases of mesothelioma emerge, new case studies are published and the number of cases analyzed increases, researchers can better understand万博专业版间皮瘤统计，癌症的进展，成功治疗，危险因素和其他将改善疾病诊断和治疗的信息。
Mesothelioma and Genetics
一项感兴趣的研究是遗传学和间皮瘤。万博专业版在过去十年中万博专业版石棉癌。During histology, specialists can look at patient DNA to observe chromosomal losses and gains, pinpointing connections in cases of patients with malignant mesothelioma. More research is needed to determine their efficacy in assisting with diagnosis and prognosis of the disease.
BAP1基因是一种肿瘤抑制基因，已显示与胰腺癌，卵巢癌，乳腺癌和恶性间皮瘤有联系。万博专业版研究发现，许多恶性间皮瘤病例对BAP1基因有所改变。万博专业版一项这样的研究评估了良性和恶性间皮瘤肿瘤。万博专业版BAP1在所有良性肿瘤中均起作用。相反，66％的间皮瘤肿瘤未表达BAP1万博专业版。BAP1尚未成为间皮瘤的官方诊断测试。万博专业版但是，研究人员说，发现BAP1损失应触发对患者的进一步评估。
Another gene commonly implicated in cancer is P53. In fact, experts say P53 is the most commonly mutated gene present in human cancers. Multiple studies have found P53 mutations in mesothelioma tumors.
研究ers continue investigating the genetic components of mesothelioma. As more genes are implicated, scientists may find ways to address these genetic changes. This information may also help develop earlier mesothelioma detection methods.
02. Continued Research
The Need for Continued Mesothelioma Research
多年来，间皮瘤的诊断工具和治疗选择以及对疾病的理解有所改善。万博专业版但是，仍然需要更多的数据，帮助早期检测的工具，更好的治疗选择和治愈癌症，这强调了持续间皮瘤癌症研究的重要性。万博专业版
研究不仅对于医生在解决和治疗该疾病时至关重要，而且对于寻求更好地了解其诊断，治疗选择和预后的患者及其亲人。
间皮瘤社万博专业版区由许多幸存者，患者，亲人，专家，研究人员，组织和基金会组成，致力于提高人们对疾病和资金的认识，以继续研究工作。
03. Research Studies
Selected Mesothelioma Research Studies
- 2018 Update on Mesothelioma Diagnosis, Staging and Treatment Guidelines
- A retrospective cohort study to evaluate patient survival in sarcomatoid mesothelioma receiving best supportive care, chemotherapy and palliative radiotherapy
- ASCO：研究证实了恶性间皮瘤中的Pemetrexed-Platinum活性万博专业版
- 贝伐单抗用于新诊断的胸膜间皮瘤，在间皮瘤avastin®Cisplatinpem万博专业版etrexed研究（地图）中：一项随机，控制，开放标签，第3阶段试验。
- 人类第一阶段1 CRISPR基因编辑癌症试验：我们准备好了吗？
- High-Quality Results of Cytoreductive Surgery and Heated Intraperitoneal Chemotherapy Perfusion for Carcinomatosis at a Low Volume Institution
- Induction radiotherapy and mesothelioma surgery
- 恶性胸膜间皮瘤：全面评论。万博专业版
- Malignant pleural mesothelioma in pregnancy.
- Mesothelioma and lung tumors attributable to asbestos among petroleum workers.
- Mesothelioma diagnosis and prognosis, are we moving beyond histology and performance status towards circulating biomarkers?
- Mesothelioma in patients with nonoccupational asbestos exposure. An evidence-based approach to causation assessment.
- 治疗恶性胸膜间皮瘤的新概念万博专业版
- Nintedanib Plus Pemetrexed/Cisplatin in Patients With Malignant Pleural Mesothelioma: Phase II Results From the Randomized, Placebo-Controlled LUME-Meso Trial
- Nintedanib显示出对恶性胸膜间皮瘤的希望万博专业版
- 恶性间皮瘤的周围性扩散导致脊髓内脊髓质量：病例报告。万博专业版
- 在恶性胸膜间皮瘤的患者中，与单独的顺铂与顺铂结合的Pemetrexed阶段研究。万博专业版
- 肺癌和恶性胸膜间皮瘤的光动力疗法万博专业版
- Photodynamic therapy for malignant pleural mesothelioma: the future of treatment?
- Probability of Cancer in Pulmonary Nodules Detected on First Screening CT
- Prognostic value of FDG PET imaging in malignant pleural mesothelioma.
- Sex difference in diffuse malignant peritoneal mesothelioma.
- Surgery in Malignant Pleural Mesothelioma
- 针对性的恶性胸膜间皮瘤的下一代测序鉴定了复发性NRAS癌基因突变万博专业版
- 恶性胸膜间皮瘤发展中的遗传敏感性万博专业版
- The Impact of Malignant Pleural Mesothelioma Histology on the Use of Surgery and Survival in a Population-Based Analysis
- Tyler Asbestos Workers: Mortality Experience in a Cohort Exposed to Amosite
- 恶性胸膜间皮瘤的诊断和治疗方面的更新万博专业版
