有效治疗间皮瘤的已知挑战之一是在早期诊断稀有癌症的难度很难。万博专业版石棉暴露后的长期潜伏期与非特异性症状相结合，通常会导致误诊，直到间皮瘤变得更加先进。万博专业版
Many studies have focused on ways to help effectivelydetect mesothelioma早期，允许更多的治疗选择和预后改善。近年来，研究人员发现了各种生物标志物，可以帮助检测间皮瘤细胞的存在，并使医生早日诊断该疾病。万博专业版研究人员还一直在进一步研究与间皮瘤相关的基因突变和融合，这可以帮助检测和更好地治疗疾病。万博专业版
一个study from 2016has even shown that compounds in a patient’s breath can quite accurately detect thepresence of malignant pleural mesothelioma。12月，该研究背后的研究人员从对间皮瘤的呼吸分析进行了更广泛的研究中发布了他们的结果，该研究证实了他们先前的结果。万博专业版
呼吸分析如何工作
Studying a patient’s breath for markers of disease, including various types of cancer, has been an interesting area of research in more recent years. Analyzing a breath sample is non-invasive, extremely time efficient, and can provide a lot of information regarding a person’s health. Though there are many methods and types of equipment that can be used for such analysis, the researchers at Gent University in Belgium behind these studies relied on multicapillary column-ion mobility spectrometry (MCC/IMS).
MCC/IMS方法已被指出仅在大约10分钟内就可以进行完整的呼吸分析。离子迁移率本身是一种分析装置，可分离和鉴定气体中的分子，并已用于检测许多物质，包括药物和炸药，以及在患有各种疾病的医疗领域。该设备非常敏感，甚至可以检测到物质的丝毫痕迹。
的MCC/IMS method works by detecting volatile organic compounds in the breath, which can infer someone’s health status. These compounds in the body are mostly blood-borne and act asbiomarkers对于特定疾病。检测某些挥发性有机化合物已帮助研究人员发现各种癌症，例如间皮瘤，肺癌和乳腺癌以及其他疾病。万博专业版
呼吸分析检测间皮瘤万博专业版
In their first released study, the researchers in Belgium analyzed breath samples of 66 patients from three specific groups:
- 23 participants already diagnosed with pleural mesothelioma
- 22位以前与石棉合作但没有疾病症状的参与者
- 21个健康受控组的参与者，没有已知的石棉暴露
通过这项研究，研究人员发现他们能够检测患有间皮瘤的人，而健康对照组和以前万博专业版石棉工人总体精度为87％。研究人员向研究人员提出的高精度和敏感性表明，通过MCC/IMS的呼吸分析可能是检测间皮瘤并充当最风险者的筛查工具的有效方法。万博专业版
Just last month, the same researchers released the results from the next phase of this study, which included a wider, more varied pool of participants. This time breath samples were collected from six groups of participants, including:
- 52例诊断患有胸膜间皮瘤的患者万博专业版
- 59前石棉工人没有疾病的迹象
- 41例良性石棉相关疾病患者
- 70例良性肺疾病患者与石棉暴露无关
- 56例诊断患有肺癌的患者
- 52 healthy participants with no past asbestos exposure
的breath tests provided varied results among the groups, though many with very high accuracy. For instance, the researchers found an accuracy of 96% when differentiating former asbestos workers and those with a benign asbestos-related disease from those diagnosed with mesothelioma.
This study served as a validation of their prior results, helping to further show that such tests could differentiate between patients with mesothelioma and those at a high risk of disease with great accuracy. Based on their results, the researchers concluded that breath analysis could be used as a screening tool to help rule out mesothelioma or detect the disease sooner. Early detection like this could greatly increase patients’ treatment options and improve overall survival.
新年的更多研究
在较早的阶段找到潜在的筛查方法或改进以诊断间皮瘤可能意味着许多患者的差异。万博专业版万博专业版间皮瘤存活率have improved very slightly over the years, but there is still a long way to go. Most patients still face a prognosis of just 1 year or maybe up to 21 months, partially because of the difficulties in detecting the disease.
This study provides hope that researchers can continue to find ways to improve diagnosing mesothelioma. With more research, this breath test may be a viable option to utilize at a larger scale when examining patients with past asbestos exposure. With other methods for breath analysis, determining the sensitivity and accuracy of other similar tests in detecting mesothelioma may also be another aspect of future clinical trials. This area of study overall is bringing exciting discoveries in diagnosing many types of cancer and disease, and hopefully will continue to be an important aspect of research in this new year.
