01.什么是NIPEC？
What Is NIPEC?
正常热腹膜化疗（NIPEC）is a liquid chemotherapy wash applied directly within the abdominal cavity. The chemotherapy is kept at room temperature and typically administered in multiple rounds.
NIPECis a treatment option for恶性腹膜间皮瘤万博专业版，以及其他腹部癌。
NIPEC与全身化疗有何不同？
Many people are familiar with systemic chemotherapy. Chemotherapy washes, such as NIPEC, differ based on how they are administered to a patient.
- Systemic chemotherapy treatment传统上是静脉内给予的（通过IV）。这种化学疗法在整个患者的血液中都传播，并且可以到达身体的任何部位。某些形式的全身化疗可能以药丸或液体形式提供。
- Chemotherapy washes consist of a liquid medication circulated in a targeted area of the body. The wash is confined to a cavity where the cancer is located.
NIPECtargets the peritoneal cavity (abdominal cavity).
How Is NIPEC Different From Other Chemotherapy Washes?
NIPECmay differ from other chemotherapy washes based on medication temperature and when the treatment is given.
NIPECis room-temperature chemotherapy typically used as a long-term course of treatment. Doctors administer the first round of NIPEC 4 – 6 weeks after surgery.
02. The NIPEC Procedure
What Does the NIPEC Procedure Entail?
NIPECis a multi-step process with multiple cycles of the chemotherapy wash. NIPEC is typically administered after cytoreductive surgery to kill remaining cancer cells. As a result, the port to administer NIPEC is usually inserted at the end of the patient’s surgical procedure.
细胞减少手术也称为细胞减少，延伸或CR。它是一个type of surgery这可以消除尽可能多的恶性组织。
NIPECmay be administered as an inpatient or outpatient procedure. For outpatient procedures, patients often aren’t required to be hospitalized throughout NIPEC treatment. In both cases, patients will spend time in the hospital after CRS for recovery.
1. Port Insertion
手术后，医生将端口插入患者的腹部。这称为腹膜内端口。
2. Chemotherapy Is Administered Through the Port
Around 4 – 6 weeks after surgery, the physician will begin administering chemotherapy through the port. The chemotherapy solution is kept at room temperature.
The first cycle of NIPEC may be completed in one day or across consecutive days. Patients will discuss a treatment schedule with their specialist.
3.施用多个NIPEC的循环
Peritoneal mesothelioma patients commonly undergo multiple cycles of NIPEC. Researchers report there are typically six cycles across six months.
As a long-term course of treatment, NIPEC is often referred to as NIPEC long-term or NIPEC-LT.
4. Port Is Removed
一旦患者完成了所有NIPEC周期，医生将从腹部清除端口。
Doctors typically advise patients to monitor the port site for signs of infection.
03.优势和缺点
Advantages and Disadvantages of NIPEC
As with all cancer treatments, there are pros and cons of undergoing NIPEC.
Patients should discuss all potential advantages and disadvantages with their oncologists.
04. NIPEC Treatment Combinations
Is NIPEC Combined With Other Treatments?
Studies show NIPEC being used alongside other cancer treatments. NIPEC is often an adjuvant therapy. In other words, it is administered after other therapies. Treatment plans consisting of multiple therapies are referred to as多模式治疗。
Research on different NIPEC treatment combinations is limited. However, existing studies have shown NIPEC used with cytoreductive surgery, HIPEC and EPIC.
If eligible for multimodal treatments, patients may be able to improve theirmesothelioma prognosis。
05. NIPEC Success Rates
How Successful Is NIPEC for Treating Mesothelioma?
NIPEChas been able to improve腹膜间皮瘤患者的5年生存率万博专业版。NIPEChas also been successful in treating ovarian cancer and gastric cancer.
In one study,Paul Sugarbaker博士reported success in extending survival in peritoneal mesothelioma patients when combining NIPEC with other cancer treatments.
与NIPEC的治疗组合表现出最高的5年生存率。Sugarbaker博士还测试了其他化学疗法洗涤的手术组合。
Another study, published in 2020, demonstrated success with NIPEC for peritoneal mesothelioma. This study was conducted at the医学斯塔尔华盛顿医院中心。Researchers worked with a small group of six peritoneal mesothelioma patients. All patients underwent at least three rounds of NIPEC.
Researchers reported patient survival of 8 – 19 years after NIPEC treatment. Some of these patients are still alive with no evidence of disease.*
*NIPEC research is limited and this data represents a small sample size of patients. Survival may vary widely in a study with more participants.
This particular study used chemotherapy drug paclitaxel. Additional studies may help researchers determine whichchemotherapy drugs最适合NIPEC治疗。
Resources for Mesothelioma Patients
06. NIPEC Side Effects
NIPEC的潜在副作用是什么?
As with other cancer treatments, NIPEC has a range of potential side effects, including:
- Loss of appetite
- Nausea
- Vomiting
- Diarrhea
- Abdominal pressure or bloating
- Sensation of needing to urinate
- Increased breathing rate
- Sepsis
- Port-site infection
- Kidney failure
- Bone marrow suppression
HIPEC，NIPEC和EPIC通常比标准化疗产生的副作用更少。全身化疗在整个患者的血液中都传播。然后，该药物与整个体内细胞相互作用。
潜在的副作用因患者而异。患者应与医生讨论并发症的风险。老年患者或整体健康状况不佳的患者可能更容易受到NIPEC的负面影响。
07. Where to Find NIPEC
Where to Find NIPEC Treatment for Mesothelioma
NIPECis not widely available in the United States for peritoneal mesothelioma patients. NIPEC is still new compared to other standard cancer treatments. Patients should consult with their specialist to determine if NIPEC is an option and where it may be available.
Mesothelioma cancer centerscontinue to expand their treatment options for mesothelioma patients as research evolves. For example, a number of treatment centers now offer HIPEC.
在追求NIPEC之前，患者应与医生讨论进行化学疗法洗涤的可能性，这是他们的治疗计划的一部分。万博专业版间皮瘤专家can provide the best insight into a patient’s individual options. Even if a patient is ineligible for NIPEC, there are other treatment options that may improve quality of life and survival.
